FEATURES

FAMILY

PA-phosphatase related phosphoesterase family

DESCRIPTION

Also known as PLPP4_HUMAN, PLPP4, DPPL2, PPAPDC1, PPAPDC1A. Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the degradation or generation of lipid-signaling molecules like diacylglycerol (PubMed:28851360).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PLPP4

Phospholipid phosphatase 4

PLPP4

Molecular Synopsis