FEATURES

DESCRIPTION

Also known as CAR17_HUMAN, CARD17P, CARD17, INCA. Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation. Interacts with pro-CASP1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CARD17P

Putative caspase recruitment domain-containing protein 17P

CARD17P

Molecular Synopsis