FEATURES

FAMILY

DESCRIPTION

Also known as CP135_HUMAN, CEP135, CEP4, KIAA0635. Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). Interacts with DCTN2 (By similarity). Interacts with CEP250 (PubMed:18851962).

EXTERNAL LINKS

CEP135

Centrosomal protein of 135 kDa

CEP135

Molecular Synopsis