FEATURES

FAMILY

DESCRIPTION

Also known as SLN13_HUMAN, SLFN13. Endoribonuclease that cleaves tRNAs and rRNAs (PubMed:29563550). Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem (PubMed:29563550). Does not act on tRNA(Sec) (PubMed:29563550). Able to restrict HIV-1 virus replication; ability to inhibit HIV-1 replication is dependent on endoribonuclease activity (PubMed:29563550).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SLFN13

Schlafen family member 13

SLFN13

Molecular Synopsis