FEATURES

FAMILY

secreted frizzled-related protein (sFRP) family

DESCRIPTION

Also known as SFRP4_HUMAN, SFRP4, FRPHE. Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SFRP4

Secreted frizzled-related protein 4

SFRP4

Molecular Synopsis