FEATURES

FAMILY

DESCRIPTION

Also known as P20D1_HUMAN, PM20D1. Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase (PubMed:27374330). It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction (PubMed:27374330). Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL, respectively) lipoprotein particles (By similarity).

EXTERNAL LINKS

PM20D1

N-fatty-acyl-amino acid synthase/hydrolase PM20D1

PM20D1

Molecular Synopsis