FEATURES

FAMILY

DESCRIPTION

Also known as P4R3A_HUMAN, PPP4R3A, KIAA2010, PP4R3A, SMEK1. Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3A. Interacts with PPP4C; the interaction requires PPP4R2.

Also known as P4R3A_HUMAN, PPP4R3A, KIAA2010, PP4R3A, SMEK1. Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PPP4R3A

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

PPP4R3A

Molecular Synopsis