FEATURES

FAMILY

DESCRIPTION

Also known as IFIX_HUMAN, PYHIN1, IFIX. Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. Interacts with MDM2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PYHIN1

Pyrin and HIN domain-containing protein 1

PYHIN1

Molecular Synopsis