FEATURES

DESCRIPTION

Also known as PMF1_HUMAN, PMF1. Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT. Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Interacts with COPS7A. Interacts via its coiled-coil domain with the leucine-zipper domain of NFE2L2. The interaction with NFE2L2 is required for the transcriptional regulation of SSAT.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PMF1

Polyamine-modulated factor 1

PMF1

Molecular Synopsis