FEATURES

DESCRIPTION

Also known as FBX42_HUMAN, FBXO42, FBX42, JFK, KIAA1332. Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. Component of some SCF complex, composed of CUL1, SKP1, RBX1 and FBXO42. Interacts (via the kelch domain) with p53/TP53; interaction is direct.

Also known as FBX42_HUMAN, FBXO42, FBX42, JFK, KIAA1332. Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FBXO42

F-box only protein 42

FBXO42

Molecular Synopsis