FEATURES

FAMILY

ANT/ATPSC lysine N-methyltransferase family

DESCRIPTION

Also known as ACKMT_HUMAN, ATPSCKMT, FAM173B. Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (PubMed:29444090, PubMed:30530489). Promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090).

EXTERNAL LINKS

ATPSCKMT

ATP synthase subunit C lysine N-methyltransferase

ATPSCKMT

Molecular Synopsis