FEATURES

FAMILY

DESCRIPTION

Also known as NOTUM_HUMAN, NOTUM. Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NOTUM

Palmitoleoyl-protein carboxylesterase NOTUM

NOTUM

Molecular Synopsis