FEATURES

DESCRIPTION

Also known as BRAT1_HUMAN, BRAT1, BAAT1, C7orf27. Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). Interacts with BRCA1 and ATM. Interacts with MTOR and RPTOR. Interacts with NDFIP1. Interacts with SMC1A and PRKDC.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

BRAT1

BRCA1-associated ATM activator 1

BRAT1

Molecular Synopsis