FEATURES

FAMILY

DESCRIPTION

Also known as PAOX_HUMAN, PAOX, PAO. Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1), N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12477380). Monomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PAOX

Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

PAOX

Molecular Synopsis