FEATURES

DESCRIPTION

Also known as CLC9A_HUMAN, CLEC9A. Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CLEC9A

C-type lectin domain family 9 member A

CLEC9A

Molecular Synopsis