FEATURES

FAMILY

DESCRIPTION

Also known as RN19B_HUMAN, RNF19B, IBRDC3, NKLAM. E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (PubMed:16709802, PubMed:27485036). Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (PubMed:10438909). Protects against staurosporin-induced cell death (PubMed:27485036). Interacts with UBE2L3, UBE2L6 and UCKL1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RNF19B

E3 ubiquitin-protein ligase RNF19B

RNF19B

Molecular Synopsis