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FEATURES

FAMILY

DEF8 family

DESCRIPTION

Also known as DEFI8_HUMAN, DEF8. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. Interacts (via C-terminus) with PLEKHM1; this interaction is weak but increased in a RAB7A-dependent manner.

Also known as DEFI8_HUMAN, DEF8. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. Interacts (via C-terminus) with PLEKHM ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DEF8

Differentially expressed in FDCP 8 homolog

Molecular Synopsis

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