FEATURES

FAMILY

organo anion transporter (TC 2.A.60) family

DESCRIPTION

Also known as SO4C1_HUMAN, SLCO4C1, OATP4C1, OATPX, SLC21A20. Mediates the transport of organic anions such as estrone 3-sulfate and thyroid hormones 3, 3', 5'-triiodo-L-thyronine (T3) and L-thyroxine (T4) (PubMed:14993604, PubMed:19129463). Capable of transporting pharmacological substances such as digoxin, ouabain, methotrexate and cAMP (PubMed:14993604). Shows a pH-sensitive substrate specificity estrone 3-sulfate and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). May participate in the regulation of membrane transport of ouabain (PubMed:14993604). Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells (PubMed:17314201). May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney (PubMed:14993604). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells (By similarity). This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation (By similarity). May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity).

EXTERNAL LINKS

SLCO4C1

Solute carrier organic anion transporter family member 4C1

SLCO4C1

Molecular Synopsis