FEATURES

DESCRIPTION

Also known as RN207_HUMAN, RNF207, C1orf188. Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner. Interacts with the core-glycosylated, but not the fully glycosylated form of KCNH2/HERG. Interacts with DNAJA1 and HSPA8. Interacts (via the C-terminus) with HSPA1A; this interaction additively increases KCNH2 expression.

Also known as RN207_HUMAN, RNF207, C1orf188. Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RNF207

RING finger protein 207

RNF207

Molecular Synopsis