FEATURES

FAMILY

DESCRIPTION

Also known as UBR3_HUMAN, UBR3, KIAA2024, ZNF650. E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed:27331610). Interacts with UBE2A and UBE2B.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

UBR3

E3 ubiquitin-protein ligase UBR3

UBR3

Molecular Synopsis