FEATURES

DESCRIPTION

Also known as AN13D_HUMAN, ANKRD13D. Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. Interacts with EGFR (ubiquitinated); the interaction is direct and may regulate EGFR internalization.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ANKRD13D

Ankyrin repeat domain-containing protein 13D

ANKRD13D

Molecular Synopsis