FEATURES

FAMILY

DESCRIPTION

Also known as SEP14_HUMAN, SEPTIN14, SEPT14. Filament-forming cytoskeletal GTPase (Probable). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Plays a role in sperm head formation during spermiogenesis, potentially via facilitating localization of ACTN4 to cell filaments (PubMed:33228246). Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with ACTN4 (PubMed:33228246). Interacts with SEPTIN9 (PubMed:17922164). Interacts (via C-terminus) with SEPTIN4 (By similarity).

EXTERNAL LINKS

SEPTIN14

Septin-14

SEPTIN14

Molecular Synopsis