FEATURES

FAMILY

DESCRIPTION

Also known as NUD18_HUMAN, NUDT18, MTH3. Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7, 8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NUDT18

8-oxo-dGDP phosphatase NUDT18

NUDT18

Molecular Synopsis