FEATURES

FAMILY

repulsive guidance molecule (RGM) family

DESCRIPTION

Also known as RGMC_HUMAN, HJV, HFE2, RGMC. Acts as a bone morphogenetic protein (BMP) coreceptor (PubMed:18976966). Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis (PubMed:18976966). Interacts with BMP2 and BMP4 (By similarity). Interacts with BMP6 (By similarity). Interacts with BMPR1B (PubMed:16604073). Interacts with TMPRSS6 (PubMed:18976966, PubMed:19357398).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HJV

Hemojuvelin

HJV

Molecular Synopsis