FEATURES

FAMILY

DESCRIPTION

Also known as TMTC3_HUMAN, TMTC3. Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3 (PubMed:28973932). Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TMTC3

Protein O-mannosyl-transferase TMTC3

TMTC3

Molecular Synopsis