FEATURES

DESCRIPTION

Also known as PREX2_HUMAN, PREX2, DEPDC2. Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3, 4, 5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase. Interacts with RAC1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PREX2

Phosphatidylinositol 3, 4, 5-trisphosphate-dependent Rac exchanger 2 protein

PREX2

Molecular Synopsis