FEATURES

FAMILY

Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family

DESCRIPTION

Also known as NCKX5_HUMAN, SLC24A5, JSX, NCKX5. Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+) (PubMed:18166528). Involved in pigmentation, possibly by participating in ion transport in melanosomes (PubMed:16357253, PubMed:18166528). Predominant sodium-calcium exchanger in melanocytes (PubMed:16357253, PubMed:18166528).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SLC24A5

Sodium/potassium/calcium exchanger 5

SLC24A5

Molecular Synopsis