FEATURES

FAMILY

DESCRIPTION

Also known as 5MP2_HUMAN, BZW1, 5MP2, BZAP45, KIAA0005. Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:29470543, PubMed:34260931). Enhances histone H4 gene transcription but does not seem to bind DNA directly (PubMed:11524015).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

BZW1

eIF5-mimic protein 2

BZW1

Molecular Synopsis