FEATURES

FAMILY

DESCRIPTION

Also known as CHST9_HUMAN, CHST9. Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1, GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CHST9

Carbohydrate sulfotransferase 9

CHST9

Molecular Synopsis