FEATURES

FAMILY

ribonucleoside diphosphate reductase small chain family

DESCRIPTION

Also known as RIR2B_HUMAN, RRM2B, P53R2. Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. Heterotetramer with large (RRM1) subunit. Interacts with p53/TP53. Interacts with RRM1 in response to DNA damage.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RRM2B

Ribonucleoside-diphosphate reductase subunit M2 B

RRM2B

Molecular Synopsis