FEATURES

FAMILY

DESCRIPTION

Also known as TICRR_HUMAN, TICRR, C15orf42. Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. Interacts with TOPBP1 (via BRCT domains); interaction takes place in a CDK2-dependent manner (PubMed:20080954). Component of the replisome complex composed of at least DONSON, MCM2, MCM7, PCNA and TICRR (PubMed:28191891).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TICRR

Treslin

TICRR

Molecular Synopsis