FEATURES

DESCRIPTION

Also known as LYCHS_HUMAN, GPR155, PGR22. Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway (PubMed:36007018). Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disrupt interaction between the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:36007018). Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition (PubMed:36007018). Interacts with the GATOR1 complex; preventing interaction between GATOR1 and KICSTOR; interaction is disrupted upon cholesterol starvation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GPR155

Lysosomal cholesterol signaling protein

GPR155

Molecular Synopsis