FEATURES

DESCRIPTION

Also known as POGZ_HUMAN, POGZ, KIAA0461, SUHW5, ZNF280E, ZNF635. Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387). Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5. Interacts (via IBM motif) with PSIP1 isoform 1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (PubMed:19244240, PubMed:25082813, PubMed:29997176). Interacts with HDGFL2 (PubMed:26721387).

Also known as POGZ_HUMAN, POGZ, KIAA0461, SUHW5, ZNF280E, ZNF635. Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Pro ...

EXTERNAL LINKS

POGZ

Pogo transposable element with ZNF domain

POGZ

Molecular Synopsis