FEATURES

FAMILY

DESCRIPTION

Also known as R144B_HUMAN, RNF144B, IBRDC2, P53RFP. E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. Interacts with UBE2L3, UBE2L6 and LCMT2, as well as with BAX.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RNF144B

E3 ubiquitin-protein ligase RNF144B

RNF144B

Molecular Synopsis