FEATURES

DESCRIPTION

Also known as ARHG8_HUMAN, NET1, ARHGEF8. Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. Interacts with RHOA in its GTP- and GDP-bound states, and with CDC42 in its GTP-bound state. Interacts with the PDZ 1 domain of BAIAP1 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NET1

Neuroepithelial cell-transforming gene 1 protein

NET1

Molecular Synopsis