FEATURES

DESCRIPTION

Also known as SPRE2_HUMAN, SPRED2. Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364, PubMed:34626534). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (PubMed:34626534). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). Homodimer and heterodimer (PubMed:15683364). Able to interact with SPRED1 to form heterodimers (PubMed:15683364). Interacts with RAS (By similarity). May interact with ZDHHC13 (via ANK repeats) and ZDHHC17 (via ANK repeats) (By similarity). Interacts with TESK1 (By similarity). Interacts with NF1 (PubMed:34626534).

EXTERNAL LINKS

SPRED2

Sprouty-related, EVH1 domain-containing protein 2

SPRED2

Molecular Synopsis