FEATURES

DESCRIPTION

Also known as FGD2_HUMAN, FGD2, ZFYVE4. Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4, 5-bisphosphate, phosphatidylinositol 3, 4, 5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FGD2

FYVE, RhoGEF and PH domain-containing protein 2

FGD2

Molecular Synopsis