FEATURES

DESCRIPTION

Also known as FRMD5_HUMAN, FRMD5. May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675). Interacts with CTNND1 (PubMed:22846708). Interacts with ITGB5 (via cytoplasmic domain) and ROCK1 (PubMed:25448675).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FRMD5

FERM domain-containing protein 5

FRMD5

Molecular Synopsis