FEATURES

DESCRIPTION

Also known as FBX33_HUMAN, FBXO33, FBX33. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity). Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO33) formed of CUL1, SKP1, RBX1 and FBXO33. Interacts via its N-terminus with YBX1 CSD domain. Directly interacts with SKP1 and CUL1 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FBXO33

F-box only protein 33

FBXO33

Molecular Synopsis