FEATURES

FAMILY

DESCRIPTION

Also known as CTU1_HUMAN, CTU1, ATPBD3, NCS6. Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2.

Also known as CTU1_HUMAN, CTU1, ATPBD3, NCS6. Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CTU1

Cytoplasmic tRNA 2-thiolation protein 1

CTU1

Molecular Synopsis