FEATURES

FAMILY

DESCRIPTION

Also known as VP13B_HUMAN, VPS13B, CHS1, COH1, KIAA0532. Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:30962439, PubMed:24334764, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity). Interacts with STX6 (By similarity). Interacts with STX12 (By similarity). Interacts with RAB6A isoform 1 (GTP-bound) and isoform 2 (GTP-bound) (PubMed:25492866). Interacts with RAB6B (GTP-bound) (PubMed:25492866).

EXTERNAL LINKS

VPS13B

Intermembrane lipid transfer protein VPS13B

VPS13B

Molecular Synopsis