FEATURES

FAMILY

krueppel C2H2-type zinc-finger protein family

DESCRIPTION

Also known as ZN467_HUMAN, ZNF467. Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex (By similarity). Interacts with STAT3. Enhances STAT3 activity by keeping it in the nucleus (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ZNF467

Zinc finger protein 467

ZNF467

Molecular Synopsis