FEATURES

FAMILY

DESCRIPTION

Also known as NPM2_HUMAN, NPM2. Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization. Homopentamer, when bound to H2A-H2B dimers only. Homodecamer of two stacked pentamers, when bound to H2A-H2B dimers and H3-H4 tetramers simultaneously.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NPM2

Nucleoplasmin-2

NPM2

Molecular Synopsis