FEATURES

DESCRIPTION

Also known as PP4P1_HUMAN, PIP4P1, C14orf9, TMEM55B. Catalyzes the hydrolysis of phosphatidylinositol-4, 5-bisphosphate (PtdIns-4, 5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3, 4, 5-trisphosphate, phosphatidylinositol 3, 4-bisphosphate, inositol 3, 5-bisphosphate, inositol 3, 4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (PubMed:29146937). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (PubMed:29644770). May play a role in the regulation of cellular cholesterol metabolism (PubMed:25035345). Interacts (via transmembrane domain) with ATP6V0D1 (PubMed:29644770). Interacts with LAMTOR1 (PubMed:29644770). Interacts with RRAGA and RRAGC (By similarity).

EXTERNAL LINKS

PIP4P1

Type 1 phosphatidylinositol 4, 5-bisphosphate 4-phosphatase

PIP4P1

Molecular Synopsis