FEATURES

FAMILY

DESCRIPTION

Also known as PATL1_HUMAN, PATL1. RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261)., (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). Interacts (via region A) with DDX6/RCK (PubMed:20543818, PubMed:20584987, PubMed:31422817, PubMed:31439631). Interacts (via region H and region C) with LSM1 and LSM4 (PubMed:20584987, PubMed:20852261). Interacts (via region N) with DCP1A, DCP2, EDC3, EDC4 and XRN1 (PubMed:20584987, PubMed:20543818). Interacts with the CCR4-NOT complex (PubMed:20584987). Interacts with the Lsm-containing SMN-Sm protein complex (PubMed:20543818). Interacts with EIF4ENIF1/4E-T (PubMed:26027925, PubMed:32354837).

EXTERNAL LINKS

PATL1

Protein PAT1 homolog 1

PATL1

Molecular Synopsis