FEATURES

DESCRIPTION

Also known as LYRIC_HUMAN, MTDH, AEG1, LYRIC. Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. Interacts with BCCIP, CREBBP/CBP and RELA/p65.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MTDH

Protein LYRIC

MTDH

Molecular Synopsis