FEATURES

DESCRIPTION

Also known as CATAC_HUMAN, CENATAC. Negative regulator of centrosome duplication (PubMed:31722219). Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner. SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly. The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1 (PubMed:31722219). Interacts with SASS6; the interaction increases with CENATAC acetylation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CENATAC

Centrosomal AT-AC splicing factor

CENATAC

Molecular Synopsis