FEATURES

FAMILY

DESCRIPTION

Also known as SHLD2_HUMAN, SHLD2, FAM35A, RINN2. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). Component of the shieldin complex, consisting of SHLD1, SHLD2, SHLD3 and MAD2L2/REV7 (PubMed:29656893, PubMed:29789392). Within the complex, SHLD2 forms a scaffold which interacts with a SHLD3-MAD2L2 subcomplex via its N-terminus, and with SHLD1 via its C-terminus (PubMed:29656893). Interacts with TP53BP1 (PubMed:29789392). Interacts with RIF1 (PubMed:29789392).

Also known as SHLD2_HUMAN, SHLD2, FAM35A, RINN2. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392) ...

EXTERNAL LINKS

SHLD2

Shieldin complex subunit 2

SHLD2

Molecular Synopsis