FEATURES

FAMILY

DESCRIPTION

Also known as TIKI1_HUMAN, TRABD2A, C2orf89, TIKI1. Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TRABD2A

Metalloprotease TIKI1

TRABD2A

Molecular Synopsis