FEATURES

DESCRIPTION

Also known as KBTB6_HUMAN, KBTBD6. As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205). Core component of a BCR3 (BTB-CUL3-RBX1) E3 ubiquitin ligase complex, also named Cul3-RING ubiquitin ligase complex CUL3(KBTBD6/7), composed of CUL3, RBX1, KBTBD6 and KBTBD7 (PubMed:25684205). Interacts with GABARAP; the interaction is direct and is required for the ubiquitination of TIAM1 (PubMed:25684205). Interacts with GABARAPL1, GABARAPL2 and MAP1LC3B; the interaction is direct (PubMed:25684205).

EXTERNAL LINKS

KBTBD6

Kelch repeat and BTB domain-containing protein 6

KBTBD6

Molecular Synopsis